Custom Peptides
Cayman Chemical TaccalonlIde AJ 10mg
A taccalonolide with anticancer activity; enhances microtubule polymerization in a cell-free assay from 5-30 µM; inhibits the proliferation of HeLa cells (IC50 = 4 nM)
Cayman Chemical HInokIflavon 10mg
A biflavonoid with diverse biological activities; inhibits the aggregation of Aβ40 in vitro (IC50 = 9.5 μM); promotes pre-mRNA splicing of the genes encoding Mcl-1 and eIF4α and inhibits pre-mRNA splicing of the genes encoding Hsp40 and RIOK3 in NB4 cells at 10 µM; increases protein SUMOylation in HEK293 cells at 10 µM; reduces the cytopathic effect of the influenza A subtypes H1N1 and H1N3, influenza B, parainfluenza type 3, and RSV (IC50s = 1.4, 1.3, 1.2, 1, and 2.5 UG/ml, respectively); inhibits the migration and invasion of, and induces apoptosis in, KYSE-150 cells from 10-40 µM; reduces tumor volume in a KYSE-150 mouse xenograft model at 25 or 50 mg/kg
Cayman Chemical Abrocitinib 10mg
A JAK1 inhibitor (IC50 = 0.029 µM); selective for JAK1 over JAK2, JAK3, and TYK2 (IC50s = 0.803, >10, and 1.253 µM, respectively) and a panel of 40 kinases at 1 µM; inhibits IFN-α-, IL-21-, or IL-27-induced phosphorylation of STAT3 (IC50s = 0.189, 0.511, and 0.271 µM, respectively) and IFN-γ-induced phosphorylation of STAT1 (IC50 = 0.163 µM) in isolated human whole blood; reduces paw edema in a rat model of adjuvant-induced arthritis at 1, 5, and 15 mg/kg
Cayman Chemical 1LInoleoyl3aLInolenoylra 10mg
A diacylglycerol; has been found in olive oil subjected to lipase-catalyzed glycerolysis with immobilized lipase B from C. antarctica
Cayman Chemical BMK methyl glycIdate 10mg
An analytical reference standard categorized as a precursor in the synthesis of phenylacetone; intended for research and forensic applications
Cayman Chemical PTI-1hydrochlorIde 10mg
A synthetic cannabinoid (CB) that contains the 1-pentyl-indole structure found in potent agonists of the central cannabinoid (CB1) receptor, like JWH 018 (Item No. 10900), linked to a thiazole-based side chain; intended for forensic and research applications
Cayman Chemical SynthetIc DIMBOA 10mg
A benzoxazinoid with antimicrobial and antioxidant activities; active against S. aureus, E. faecalis, E. coli, K. pneumoniae, B. subtilis, and P. aeruginosa, as well as S. cerevisiae, in a disc assay at 2 mg/disc; scavenges DPPH radicals in a cell-free assay (IC50 = 11.31 UG/ml)
Cayman Chemical SynthetIc NIgerose 10mg
A disaccharide; prevents increases in MDA and ROS levels and inhibits LDH release in HL-60 cells post-cryopreservation at 150 µM in combination with salidroside
Cayman Chemical TIplaxtInIn 10mg
A PAI-1 inhibitor (IC50 = 2.7 µM for the human enzyme); inhibits differentiation of human adipocytes at 5 µM; reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model at 5 and 20 mg/kg; prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis at 1 mg/kg
Cayman Chemical MescalIn NBOMehydrochLRId 10mg
A derivative of mescaline having an N-(2-methoxybenzyl) addition at the amine
Cayman Chemical Senecionine 10mg
A pyrrolizidine alkaloid with hepatotoxic properties; metabolized by CYP3A in the liver to the detoxification product senecionine N-oxide and reactive metabolites including dehydropyrrolizidine alkaloids and dehydrotetronecine; induces mitochondrial depolarization and fragmentation in primary cultured mouse hepatocytes at 20 μM and increases apoptosis in a concentration-dependent manner; induces liver injury, increases serum levels of bilirubin and various bile acids, including taurocholic acid, glycocholic acid, and deoxycholic acid, and increases the activity of alanine aminotransferase and aspartate aminotransferase in serum in rats at 35 mg/kg; hepatotoxicity is also associated with lipid peroxidation and glutathione depletion
Cayman Chemical Maltotetraose 10mg
A tetrasaccharide; increases the α-amylase synthesis rate in B. stearothermophilus three-fold greater than sucrose or glucose when used at at 0.1 mM; inhibits the growth of E. carotovora in a cylinder-agar plate assay at 750 μg/ml; inhibits TNF-α-induced expression of ICAM-1 in MOVAS-1 mouse VSMCs
Cayman Chemical SynthetIcE-Ajoen 10mg
A disulfide with diverse biological activities; active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 UG/ml, respectively) and fungi (MICs = 15-50 UG/ml); inhibits proliferation of a variety of cancer cells (IC50s = 18.6-61 µM); inhibits human glutathione reductase and T. cruzi trypanothione reductase at 200 µM; neuroprotective in a gerbil model of ischemia-reperfusion injury, reducing reactive astrocytosis and microgliosis in the hippocampal CA1 region at 25 mg/kg
Cayman Chemical OmadacyclIn 10mg
An aminomethylcycline antibiotic; active against tetracycline-susceptible and -resistant strains of S. aureus, E. faecalis, E. faecium, S. pneumoniae, and E. coli, as well as β-hemolytic streptococci (MICs = ≤0.06-2 UG/ml); efficacious in mouse models of systemic infection with tetracycline-sensitive and -resistant strains of S. pneumoniae, S. aureus, or E. coli (ED50s = 0.3-3.34 mg/kg)
Cayman Chemical L-CycloserIn 10mg
An inhibitor of sphingolipid synthesis and aminotransferases; inhibits bacterial SPT 100 times more potently than D-cycloserine; inhibits SPT activity up to 86% in a dose-dependent manner in mouse brain microsomes following administration of doses ranging from 25-200 mg/kg; inhibits SPT in rabbit aorta and several aminotransferases in vitro and in vivo in rat; inhibits the growth of M. tuberculosis through branched chain aminotransferase inactivation, and it does so more rapidly and potently than D-cycloserine (MICs = 0.3 and 2.3 UG/ml, respectively)